Prevent using acetaminophen and codeine phosphate tablets in adolescents 12 to 18 several years of age who produce other danger factors which will improve their sensitivity on the respiratory depressant effects of codeine Except if the advantages outweigh the dangers.
Misuse and abuse of acetaminophen and codeine phosphate tablets raises possibility of overdose, which may result in central anxious method and respiratory despair, hypotension, seizures, and death. The danger is increased with concurrent abuse of acetaminophen and codeine phosphate tablets with Liquor and also other CNS depressants.
If this SPL contains inactivated NDCs detailed by the FDA initiated compliance motion, they will be specified as such.
Vigorous supportive therapy is needed in extreme intoxication. Strategies to Restrict the continuing absorption on the drug must be readily carried out Considering that the hepatic damage is dose-dependent and occurs early in the midst of intoxication.
Monitor patients for danger of substance use Diseases, such as opioid abuse and misuse, and warn them of the risk for overdose and Demise linked to the use of further CNS depressants like Alcoholic beverages and illicit prescription drugs (see PRECAUTIONS, Drug Interactions and knowledge for People/Caregivers).
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Acetaminophen and codeine phosphate tablets may impair the mental or Actual physical skills necessary to carry out possibly dangerous pursuits which include driving a car or truck or running machinery.
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On top of that, youngsters with obstructive slumber apnea who are handled with codeine for article-tonsillectomy and/or adenoidectomy soreness may be specifically delicate to its respiratory depressant result. As a result of risk of life-threatening respiratory despair and Dying: Acetaminophen and codeine phosphate tablets are contraindicated for all young children young than 12 decades of age (see CONTRAINDICATIONS).
Drug dependancy is actually a cluster of behavioral, cognitive, and physiological phenomena that may incorporate a solid want to go ahead and take drug, issues in controlling drug use (e.
Codeine really should not be used for soreness aid in kids and adolescents soon after removing of their tonsils or adenoids resulting from Obstructive Slumber Apnoea Syndrome.
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Other much less frequently noticed adverse reactions predicted from opioid analgesics, which includes acetaminophen and codeine phosphate tablets: